Fig 1.
LncRNAs can behave like an oncogene-long noncoding RNA (OncoLncs) [14] or as a tumor suppressor long noncoding RNA (TSLncs) [15, 16]. Non-coding RNAs, such as lncRNAs and miRNAs, are now known to have a role in a wide variety of processes that lead to a wide variety of disorders [17]. LncRNAs serve as potential diagnostic biomarkers for HCC with high sensitivity and specificity [18]. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) and cancer susceptibility candidate 2 (CASC2) are LncRNA that are dysregulated in HCC tissue [19, 20].
Table 1.
Primer sequences for studied LncRNAs and internal control.
Table 2.
Comparisons of routine investigations and, liver function tests in different study groups.
Fig 2.
Comparisons of lncRNA MALAT1 and CASC2 fold change in blood of different study groups.
Table 3.
Comparisons of lncRNA MALAT1 and CASC2 fold change in blood of different study groups.
Table 4.
LncRNAs MALAT1 and CASC2 markers deregulated expression among HCV and HCC study group.
Table 5.
CT finding in the HCC group and its relation to MALAT1 and CASC2 serum level.
Fig 3.
ROC analysis of MALAT1 and CASC2 for HCC diagnosis.
Table 6.
Sensitivity and specificity of MALAT and CASC2 marker in the diagnosis of HCC.