Table 1.
EAD risk factors by donor, procurement, and recipient characteristics.
Fig 1.
Pathophysiology of hepatic ischemia reperfusion injury.
ATP indicates adenosine triphosphate; ROS, reactive oxygen species; DAMPS, damage associated molecular patterns; NF-κB, nuclear factor-kappaB; MMPs, matrix metalloproteinases; NO, nitric oxide. Figure created with Biorender.com.
Fig 2.
OLT indicates orthotopic liver transplantation; ICU, intensive care unit; SOC, standard of care; CBC, complete blood count; CMP, comprehensive metabolic panel; INR, international normalized ratio; ABG, arterial blood gas; AST, aspartate aminotransferase; ALT, alanine transaminase; EAD, early allograft dysfunction; AKI, acute kidney injury; PNA, pneumonia; CXR, chest x-ray; CT scan, computed tomography scan. Figure created with Biorender.com.
Table 2.
Eligibility criteria.
Table 3.
Primary and secondary outcomes.
Table 4.
Serum biomarker panel with rationale.
Table 5.
Subject serum lab evaluation timeline.
Table 6.
Summary of serum biosample collection and processing.