Fig 1.
SPIRIT schedule of enrollment, interventions, and assessments.
Fig 2.
Timeline for enrollment and participation in the NAVSaH clinical trial by participants.
Cerebrospinal fluid (CSF).
Fig 3.
Target for auricular vagus nerve stimulation.
Vagus nerve stimulation is administered by placing the stimulating electrodes along the concha of the ear, where the innervation of the auricular branch of the vagus nerve runs.
Table 1.
Frequency and personnel for trial conduct auditing.