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Fig 1.

Patient flow.

CNS, central nervous system; ICCC-3, 3rd edition of the International Classification of Childhood Cancer; ICD-O-3, 3rd edition of the International Classification of Diseases for Oncology.

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Fig 2.

Area division and the specialized hospital in Japan.

Thick lines indicate the boundaries of the seven regions. The Chugoku and Shikoku regions were combined into one region, and the Kyushu and Okinawa regions were combined into one region, resulting in seven regional divisions. Thin lines indicate the boundaries of the 47 prefectures. Green circles indicate childhood cancer-hub hospitals designated in 2013 or 2019. This map was created from data on the Digital National Land Information download service under a CC BY license, with permission from the Information Utilization Division, Real Estate and Construction Economy Bureau, Ministry of Land, Infrastructure, Transport and Tourism, original copyright 2015 and 2021, respectively [28, 29].

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Table 1.

Characteristics of patients.

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Fig 3.

Pareto plot of the number of patients that were treated in each hospital by diagnostic group.

CNS, central nervous system; Malignant epithelial neo., other malignant epithelial neoplasms. The x-axis presents the cumulative percentage of hospitals to the total number of hospitals that provided treatment by diagnosis group. The y-axis presents the cumulative percentage of patients treated at each hospital to the total number of patients by diagnosis group; the cumulative percentage of patients was calculated in the descending order of the number of patients treated in each hospital.

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Table 2.

Number of patients in various treatment combinations and percentage of patients who received all treatments in the same facility.

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Table 3.

Number (percentage) of patients who received at least one type of treatment at designated hospitals.

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Table 4.

Percentage of patients who received their treatment within their residential area in the secondary healthcare area, the prefecture, and the region.

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Table 5.

Number and median of estimated car travel durations (hours).

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Table 6.

Odds ratios for the event that the estimated car travel duration exceeded 1 h.

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