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Fig 1.

SPIRIT schedule.

Data collection and treatment. Chiropractic treatment is either real or sham, while medicine is either ibuprofen or placebo medicine.

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Fig 2.

Study design.

Chiropractic spinal manipulative therapy (CSMT).

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Fig 2 Expand

Fig 3.

Expected participant flow diagram.

Chiropractic spinal manipulative therapy (CSMT).

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Fig 3 Expand

Table 1.

Inclusion criteria.

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Table 1 Expand

Table 2.

Exclusion criteria.

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Table 3.

Primary and secondary endpoints.

Chiropractic spinal manipulative therapy (CSMT).

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Table 3 Expand