Fig 1.
WGCNA analysis of systemic lupus erythematosus (SLE) and breast cancer (BC).
(A) The cluster dendrogram of co-expression genes in SLE. (B) The cluster dendrogram of co-expression genes in BC. (C) Module–trait relationships in SLE. (D) Module–trait relationships in BC. (E) The common gene shared in SLE and BC.
Fig 2.
MME expression in BRCA were compared in different clinicopathological parameters.
(A) MME expression between normal tissues and cancer tissues. (B) MME expression among different T stages. (C) MME expression among different N stages. (D) MME expression among different M stage. (E) MME expression between patients over or under age 60. (F) MME expression among different pathologic stages. (G) MME expression among patients with different PAM50 (prediction analysis of microarray50). (H) MME expression among different histological types. (I) MME expression between primary breast cancer and lung or brain metastasis samples. (J) MME expression between primary breast cancer and bone metastasis samples. *p < .05, **p < .01, and ***p < .001.
Table 1.
Clinicopathologic features of BRCA from the TCGA.
Fig 3.
MME-related gene enrichment analysis.
(A) The top 20 available experimentally determined MME-binding proteins obtained from STRING website. (B) The protein-protein interaction (PPI) network of the MME-binding proteins. (C) GO analysis of the MME-binding and interacted proteins. (D) KEGG pathway analysis of the MME-binding and interacted proteins. The color from blue to red was correlated with -log(p value).
Fig 4.
Analysis of MME expression of survival, immunotherapy response and drug sensitivity.
(A) The correlation of MME expression and RFS. (B) The correlation of MME expression and PPS. (C) The correlation of MME expression and OS. (D) The correlation of MME expression and DMFS. (E-F) The ROC plot of the association between MME expression and the response to therapy of BRCA. (G) Bubble plot of the correlation between MME mRNA expression and GDSC drug sensitivity for the top 30 ranked drugs. The color from blue to red represents the correlation between mRNA expression level and drug sensitivity (IC50, 50%inhibiting concentration).