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Fig 1.

PRISMA 2020 flow diagram.

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Table 1.

Characteristics of the studies included.

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Table 1 Expand

Fig 2.

Risk of bias assessment of the included studies.

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Table 2.

Primary outcome (pad test) of the studies included.

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Table 2 Expand

Table 3.

Secondary outcome (health-related quality of life) of the studies included.

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Fig 3.

Meta-analysis for the primary outcome (1h pad test) at week 4.

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Fig 4.

Meta-analysis for the primary outcome (24h pad test) at week 12.

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Table 4.

GRADE approach assessment.

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