Fig 1.
Timeline for study design and investigative measurements.
(Top) Timeline of prospective longitudinal study. Visit 1 and Visit 2 (red) includes: Physiological and cognitive assessments and blood draw. (Bottom) Investigative measures including physiological and cognitive assessments and circulating factors recorded at Visit 1 and 2 (red) and baseline MRI recorded at diagnosis of MCI prior to COVID-19 pandemic, and 18-month follow-up MRI (black). Red arrows indicate deep WMH, and orange arrows indicate periventricular WMH. Abbreviations: White matter hyperintensity (WMH), Functional near-infrared spectroscopy (f-NIRS), Electroencephalography (EEG), Dynamic retinal vessel analysis (DVA), Laser speckle contrast imaging (LSCI), Flow mediated dilation (FMD).
Table 1.
Summary of variables for study aims.