Fig 1.
SPIRIT schedule of enrolment, interventions, and assessments.
Timing of the TB results review is depending on local routine procedures. Tracing only applies to participants without documented HIV viral load between week 22 and 30. HIV viral load will be measured during tracing if participant was found and no viral load result between week 22 and 30 became available. SAE: Serious Adverse Event, AESI: Adverse Event of Special Interest, CrAg: Cryptococcal antigen test.
Fig 2.
Consort chart of the SaDAPT trial.
CNS: Central nervous system, CrAg: Cryptococcal antigen, CPT: Cotrimoxazole preventive therapy, TPT: Tuberculosis preventive therapy, SAE: Serious adverse event, AESI: Adverse event of special interest, VL: viral load.
Table 1.
Overview of endpoints.