Fig 1.
CELA3B immunostaining in normal tissues.
A) Strong positive cytoplasmatic CELA3B immunostaining in acinar parenchyma of the pancreas. B). Strong positive cytoplasmatic CELA3B immunostaining in acinar parenchyma, ductal epithelium of individual pancreatic ducts (*) and focal weak cytoplasmatic staining in islets of Langerhans (**). C) Focal apical “membranous” staining within the brush border of the ileum as well as positive staining in extracellular mucin and debris. D) Focal apical “membranous” staining of the colon as well as strong positive staining in extracellular debris/feces.
Fig 2.
Various patterns of CELA3B immunostaining in acinar cell carcinoma of the pancreas.
A) and B) Focal weak to strong cytoplasmatic CELA3B in individual tumor cells. C) Patchy moderate to strong cytoplasmatic immunostaining. D) Homogenous strong cytoplasmatic staining.
Fig 3.
Equivocal CELA3B immunostaining in non-pancreatic tumors.
A)-C) Focal weak to moderate cytoplasmatic fine granular staining in mucoepidermoid carcinoma of the salivary gland. D) Homogenous weak “brown staining” in acinic cell carcinoma of the salivary gland. E) Adenoid Cystic Carcinoma.
Fig 4.
Comparison of CELA3B immunostaining with CPA1 immunostaining in acinar cell carcinoma of the pancreas.
Table 1.
CELA3B immunostaining in tumors.