Fig 1.
The pure-tone average before and after the administration of cisplatin.
The averaged audiogram before the administration of cisplatin showed a down-sloping type sensorineural hearing loss. The pure-tone thresholds deteriorated significantly with the cumulative dose of cisplatin in the 6000–8000 Hz range.
Fig 2.
The prevalence of ears showing an abnormal threshold shift with a narrow band noise.
The prevalence of ears showing threshold shift with narrow-band noise (center frequency of 1000 Hz) is shown. Between 500 and 4000 Hz, the narrow-band noise elevated the pure-tone threshold (on-frequency masking, colored pale blue). At 125, 250, 6000, and 8000 Hz, only <10% of the patients showed a threshold shift with narrow band noise before the administration of cisplatin (off-frequency masking, colored black) (A). After the administration of cisplatin, threshold elevation at 125 and 250 Hz with narrow-band noise was observed in more ears (B). This tendency became more prominent at higher doses of cisplatin, and the change at 250 Hz was statistically significant (C).