Fig 1.
Illustrated figure of an example of D-index calculation.
D-index was derived from the difference between the expected neutrophil area (Ae) and the observed area under the curve (Ao). Ae was calculated from the product of 500/μl of ANC and the days of grade 4 neutropenia. Ao was calculated from the sum of the trapezoidal area under the neutrophil curve.
Fig 2.
Flow diagram of total recruitment alongside inclusion and exclusion criteria.
Table 1.
Demographics data and clinical characteristics between AML patients with IFIs and without IFIs.
Fig 3.
ROC curve analysis between the D-index, c-D-index, duration of grade 4 neutropenia and profound neutropenia for predicting IFIs.
A: Comparison between D-index and grade 4 neutropenia (AuROC of 0.937 vs. AuROC of 0.628; P <0.001), B: Comparison between D-index and profound neutropenia (AuROC of 0.937 vs. AuROC of 0.744; P <0.001), C: Comparison between c-D-index and grade 4 neutropenia (AuROC of 0.802 vs. AuROC of 0.628; P = 0.012), D: Comparison between c-D-index and profound neutropenia (AuROC of 0.802 vs. AuROC of 0.744; P = 0.295).