Table 1.
Demographic and clinical characteristics of patients with NAION and their paired GON patient by age and visual field mean deviation.
Fig 1.
Peripapillary RNFL and MRW in a NAION patient compared to GON.
Both patients had prominent superior greater than inferior visual field loss (greyscale; left). The peripapillary retinal nerve fibre layer (RNFL) thinning is prominent diffusely in the NAION case including temporally, whereas the thinning in the GON case is preferentially superotemporal and inferotemporal. The minimum rim width (MRW) grossly matches the peripapillary RNFL in the GON case. In contrast, the MRW is not thin, and is in fact, above average in the NAION case.
Table 2.
Global and sectoral peripapillary RNFL and MRW differences between NAION and GON patients.
Fig 2.
(A) The lamina cribrosa depth (μm) was significantly greater in the GON (Glaucomatous Optic Neuropathy) group than the NAION (Non-Arteritic Anterior Ischemic Optic Neuropathy) group. An example pair of cases showing greater lamina cribrosa depth in the NAION (B) compared to the GON (C). The difference between the dashed line and yellow line (anterior lamina cribrosa) is the lamina cribrosa depth. Cyan arrows indicated the minimum rim width (MRW) measurement. The ILM is demarcated by the red line. Box and whisker plots show individual data, median, and interquartile ranges. ***denotes P < 0.001.
Fig 3.
Thickness of central retinal layers.
The central retinal layers were thinner in the NAION (Non-arteritic Anterior Ischemic Optic Neuropathy) group compared to the GON (Glaucomatous Optic Neuropathy) group for the inner plexiform layer (IPL), inner nuclear layer (INL), and outer plexiform layer (OPL). There was no difference in the retinal nerve fibre layer (RNFL), ganglion cell layer (GCL), or outer nuclear layer (ONL). Box and whisker plots show individual data, median, and interquartile ranges. Correction was made for multiple comparisons using the Bonferroni method. *denotes P < 0.05 and **denotes P < 0.01.
Fig 4.
Correlations of peripapillary RNFL and MRW thickness with visual field mean deviation.
(A) NAION and GON show diverging correlations with regards to minimum rim width (MRW). A more obvious separation occurs at more negative visual field mean deviations. (B) Similar positive correlation between peripapillary retinal nerve fibre layer (RNFL) thickness and visual field mean deviation for both the NAION and GON groups.