Fig 1.
Consort diagram demonstrating subject inclusion and distribution of patients between groups.
EVT indicates endovascular thrombectomy; CTP, computed tomographic perfusion.
Fig 2.
Imaging results in the 14 Large Core Non-Mismatch patients.
Pre-treatment computed tomographic perfusion (CTP) images were post-processed on MIStar to generate lesion maps (Columns 1, 5). The ischaemic core (red) on the lesion map indicates tissue with relative cerebral blood flow (rCBF) <30%. The surrounding penumbra (green) indicates tissue with delay time (DT) >3 seconds. Sources images were also post-processed to generate ischaemic core maps using rCBF <20% (Columns 2, 6). Patients 1–7 remained as No Target Mismatch using the more conservative rCBF <20% threshold, while patients 8–14 became Target Mismatch. Lesion maps correlated to follow-up infarcts on follow-up diffusion weighted imaging (DWI) and non-contrast computed tomography (NCCT). 6/14 patients achieved good functional outcomes (90-day modified Rankin Scale [mRS] score 0–2), despite having large infarcts. ICA indicates internal carotid artery; NIHSS, National Institute of Health Stroke Scale; mTICI, modified Thrombolysis in Cerebral Infarction; Mn, middle cerebral artery (n segment); HIn, haemorrhagic infarction n; SAH, subarachnoid haemorrhage; An, anterior cerebral artery (n segment); PH1, parenchymal haematoma 1.
Table 1.
Baseline characteristics in patients with and without objective CTP.
Table 2.
Baseline characteristics.
Table 3.
Clinical, radiographic and intracranial haemorrhage outcomes.
Table 4.
Effect of penumbral salvage on clinical outcomes in Large Core Non-Mismatch patients.
Table 5.
Clinical, radiographic and intracranial haemorrhage outcomes in early and late window.