Table 1.
Subjects’ characteristics.
Table 2.
DENV serotypes and its association with plasma leakage.
Table 3.
Dengue viral load median score difference between subjects with and without plasma leakage based on the day of fever.
Fig 1.
Plasma dengue viral load in patients based on the infection history.
Significant difference between patients with primary infection and secondary infection was observed on day 5 (P = 0.033). Data are presented as median with interquartile range (IQR). Abbreviations: ns, not significant.
Fig 2.
Plasma dengue viral load in patients with and without plasma leakage based on the infection history.
Plasma viral load was compared between patients with and without plasma leakage in primary (A) and secondary (B) infections. (A) Viral load levels are significantly increased in plasma leakage patients compared to no plasma leakage group on day 4 (P = 0.010). (B) Viral load level is comparatively higher in day 1, 3 and 4 in plasma leakage patients, albeit not significant. Data are presented as median with interquartile range (IQR). *Represents a p value < 0.05; **p value < 0.01; ***p value < 0.001. Abbreviations: ns, not significant.
Fig 3.
NS1 positivity during course of illness.
NS1 positivity was analyzed (A) in all patients and (B) based on the occurrence of plasma leakage. Data are presented as proportion of subjects.
Fig 4.
Peak viral load based on the duration of circulating NS1 after 4 days.
Kruskall-Wallis’ test showed no significant difference between peak viral load levels in different duration of circulating NS1, however after 4 days, higher peak of viral load seem to be correlated with the longer duration of NS1. The peak levels between the 5-day group and 7-day group differed significantly (p = 0.037). Viral load levels are presented as log viral load.
Fig 5.
Comparison of the NS1 positivity and detected viral load.
NS1 positivity and detected viral load was analyzed head-to-head in (A) plasma leakage group and (B) no plasma leakage group. Data are presented as a proportion of subjects.