Table 1.
Characteristics of study populationa.
Fig 1.
Representative HILIC-UPLC-FLR chromatograms of plasma protein, immunoglobulin G and immunoglobulin A N-glycomes, with graphic representation of the most abundant glycan structure corresponding to each glycan peak (GP).
Fig 2.
Significant associations of plasma protein N-glycan traits with metabolic parameters in pregnancy.
Effect size represents beta coefficient estimated through regression model. Error bars represent 95% confidence intervals. B—bisecting GlcNAc; CF—core fucosylation; GP—glycan peak; G0 –agalactosylation; G1 –monogalactosylation; G3 –trigalactosylation; HB—high branching; HM—high mannose; LB—low branching; S0 –asialylation; S1 –monosialylation; S2 –disialylation; S3 –trisialylation;; *–adjusted p-value in range 0.05–0.01; **–adjusted p-value in range 0.01–0.001; ***–adjusted p-value < 0.001.
Fig 3.
Significant associations of IgG and IgA N-glycan traits with metabolic parameters in pregnancy.
Effect size represents beta coefficient estimated through regression model. Error bars represent 95% confidence intervals. B—bisecting GlcNAc; CF—core fucosylation; GP—glycan peak; G0 –agalactosylation; G1 –monogalactosylation; G2 –digalactosylation; HM—high mannose; S1 –monosialylation; S2 –disialylation; *–adjusted p-value in range 0.05–0.01; **–adjusted p-value in range 0.01–0.001; ***–adjusted p-value < 0.001.