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Fig 1.

Study flow chart.

AECOPD: Acute exacerbation of chronic obstructive pulmonary disease. COPD: Chronic obstructive pulmonary disease.

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Table 1.

Baseline characteristics of the population at admission to ICUs for severe AECOPD.

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Table 1 Expand

Table 2.

Characteristics of past medical history and COPD exacerbation.

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Table 2 Expand

Fig 2.

Summary of results for the primary outcome (death or invasive mechanical ventilation at day 28).

Heterogeneity for COPD severity subgroups: Chi2 = 3.50, df = 2, p = 0.32. Heterogeneity for ventilatory support subgroups: Chi2 = 6.36, df = 2, p = 0.10. Heterogeneity for SAPS II subgroups: Chi2 = 5,26, df = 1, p = 0.15. COPD: Chronic obstructive pulmonary disease. NIV: Non-Invasive Ventilation. IMV: Invasive Mechanical Ventilation. SAPS II: The Simplified Acute Physiology Score II.

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Fig 2 Expand

Table 3.

Adverse events according to corticosteroids prescription for AECOPD at admission to ICU.

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Table 3 Expand