Table 1.
Baseline patient characteristics.
Table 2.
Patient observations, investigation results and complications.
Fig 1.
Kaplan Meier curves showing inpatient survival in coronavirus disease 19 (COVID-19) patients with normal versus elevated high sensitivity cardiac troponin T (hs-cTnT).
Fig 2.
A Forrest plot showing the hazard ratios (HR) of multiple variables for inpatient mortality, as calculated using the multi-variate Cox proportional-hazard regression analysis.
HR are displayed with 95% confidence intervals (CI). AF: Atrial fibrillation; BAME: Black, Asian and minority ethnic; CKD: Chronic kidney disease; COPD: Chronic obstructive pulmonary disease; IHD: Ischaemic heart disease; TIA: Transient ischaemic attack; Hs-cTnT: High sensitivity cardiac troponin T.
Table 3.
Univariate cox regression analysis of predictors of mortality in COVID-19.
Fig 3.
Receiver-Operating Characteristic (ROC) curve of the diagnostic performance of high sensitivity cardiac troponin T (hs-cTnT) for predicting inpatient mortality in patients with coronavirus disease 19 (COVID-19).
A total of 191 patients were included in the ROC analysis. The hs-cTnT threshold of 14 ng/L was based on the 99th percentile of healthy individuals (denoted by the filled dot in the top panel). The hs-cTnT threshold of 23 ng/L was based on the Youden point of the ROC curve (denoted by the empty dot in the bottom panel). AUC denotes area under the ROC curve; values in brackets denote the 95% confidence interval for the AUC with p value <0.0001.
Table 4.
Diagnostic parameters of hs-cTnT thresholds for inpatient mortality.
Fig 4.
Whether hs-cTnT can be used to assist clinical assessment to decide on patient discharge or inpatient treatment requires further investigation, as denoted by the orange panel. Hs-cTnT: High sensitivity cardiac troponin T.