Fig 1.
Generation and detection of C3M fragments.
C3M is generated by degradation of collagen type III by the matrix metalloproteinase (MMP)-9, which produces a 10 amino acid neo-epitope (KNGETGPQGP). The ELISA antibody detects this neo-epitope and can thereby detect fragments of down to 10 amino acids. ELISA: enzyme-linked immunosorbent assay.
Table 1.
Baseline characteristics of the total population and stratified by sC3M tertiles.
Table 2.
Unadjusted and adjusted correlations between serum and urine C3M and markers of inflammation and endothelial dysfunction.
Table 3.
Unadjusted and adjusted associations between serum and urine C3M and development of cardiovascular events, all-cause mortality and decline in eGFR.
Fig 2.
Cox survival plot of decline in eGFR >3 0% for sC3M and uC3M.
Adjustment included sex, age, body mass index, LDL cholesterol, smoking, HbA1c, plasma creatinine, systolic blood pressure and urinary albumin excretion rate. uC3M: urinary C3M, sC3M: serum C3M.