Table 1.
Data sources, numbers of births and level of neonatal care provided in each region in the Co-OPT ACS cohort.
Table 2.
Variables in the Co-OPT ACS cohort and data availability from contributing regions.
Fig 1.
Data flow diagram for Co-OPT ACS cohort.
ACS = Antenatal corticosteroids. NHS = National Health Service. SMR02 = Maternity Inpatient and Day Case Scottish Morbidity Records. SMR11 = Neonatal Scottish Morbidity Records.
Table 3.
Data completeness for key maternal and neonatal variables within Co-OPT ACS cohort, per region, and in the whole cohort (%).
Table 4.
Characteristics of the Co-OPT ACS cohort (n = 2,276,156).
Fig 2.
Gestational age at birth in the Co-OPT ACS cohort.
(A) Gestational age at birth in singletons births. (all) = All singleton babies in the Co-OPT ACS cohort (live births and stillbirths). (wk) = completed weeks of gestation. (B) Gestational age at birth in multiple births. (all) = All multiple babies in the Co-OPT ACS cohort (live births and stillbirths). (wk) = completed weeks of gestation.
Fig 3.
Modes of birth in the Co-OPT ACS cohort over time.
Includes live births and stillbirths, and singleton and multiple births. The acute rise in proportion of vaginal births in the whole cohort (“all”) in 2006 reflects births in Finland joining the Co-OPT ACS cohort. The final year in the whole cohort panel (2019) contains data from Israel alone. CS = Caesarean section. (all) = All babies in the Co-OPT ACS cohort.
Fig 4.
Rates of ACS exposure in the ACS cohort.
(A) Overall rates of ACS exposure in the Co-OPT ACS cohort. (B) Rates of ACS exposure in the Co-OPT ACS cohort over time. (C) Rates of ACS exposure in singleton births in the Co-OPT ACS cohort, based on gestational age at birth. (D) Rates of ACS exposure in multiple births in the Co-OPT ACS cohort based on gestational age at birth. Fig 4A-4D include live births and stillbirths. Singleton and multiple births are presented in Fig 4A-4C includes singleton births only and Fig 4D includes multiple births only. Cases with missing ACS data were excluded. (wk) = completed weeks of gestation. (all) = All babies in the Co-OPT ACS cohort. ACS = exposed to antenatal corticosteroids.
Fig 5.
ACS-exposed births in Nova Scotia categorised by time intervals between ACS administration and birth.
h = hours. d = days.
Fig 6.
Gestational age at ACS administration (first dose) for subset of Scotland births in Aberdeen, and categorised by gestational age groups.
(wk) = completed weeks of gestation.
Table 5.
Rates of Child Health Systems Programme Pre-School reviews for live births from SMR02 (with Child Indexes).