Table 1.
Overview of the 20 studies included in this subjective retrospective analysis.
Table 2.
Overview of results per study; the table presents all findings that were called out by the study director; findings are allocated to four different categories; NOAEL describes the dose level that was selected as NOAEL by the study director.
For each finding it is indicated whether or not concordance occurred between the original interpretation and the subjective interpretation after omission of the control group. The data behind this table is provided in S1 Table.
Fig 1.
Mean anti-KLH IgG titer from a 26-week intravenous toxicity study in cynomolgus monkeys.
Animals (n = 6 per group) were allocated to 3 groups (vehicle control, low dose test article, high dose test article) and were immunized on days 32 and 60 of the dosing phase. Error bars = standard deviation. The data behind this graph is provided in S2 Table.
Table 3.
Summary of statistical analysis.
In total, 22 statistically significant results were obtained with the fixed-effect ANOVA/Dunnett’s test. Result from mixed-design ANOVA (conducted after omission of the control group) are listed on the right. The data behind this table is provided in S3 Table.