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Fig 1.

Digital imaging analysis system.

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Fig 1 Expand

Fig 2.

Photographs of a hemangioma on the left arm.

(A) The photograph acquired before treatment; (B) The photograph acquired one month after treatment; (C) The photograph taken two months after treatment; (D) The photograph acquired at the end of treatment.

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Fig 2 Expand

Fig 3.

Workflow used on the digital image analysis system.

(A) Patient information; (B) The RGB measurements; (C) Hemangioma images acquired for the patient; (D) The RGB result.

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Fig 3 Expand

Table 1.

Clinical and demographic characteristics of the patients.

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Table 1 Expand

Fig 4.

RGB ratio between the tissue around the tumor before treatment and at various time points after treatment.

** p<0.01.

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Fig 5.

RGB difference between the tissue around the tumor before treatment and at various time points after treatment.

** p<0.01.

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Table 2.

RGB mean, ratio, and difference of tumor and normal tissue around the tumor before treatment and at various time intervals after treatment.

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Table 2 Expand

Fig 6.

Bar graph illustrating the number of hemangioma for each Achauer score (1 to 5) before and at various time points after treatment.

An Achauer score of 1 means severe hemangioma, and 5 means normal skin. ** p<0.01.

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Fig 6 Expand

Fig 7.

The Spearman’s correlation between the Achuar and RGB scores.

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Fig 7 Expand

Table 3.

Number of patients within each Achuaer grade group.

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Table 3 Expand

Fig 8.

VAS scores of the patients at each treatment time.

** p<0.01.

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Fig 8 Expand

Fig 9.

The Spearman’s correlation analysis between the VAS and RGB score.

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Fig 9 Expand

Table 4.

Number of patients within the VAS scores before and after treatment.

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Table 4 Expand

Fig 10.

The HAS scores of the patients at each treatment time.

** p<0.01.

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Fig 10 Expand

Fig 11.

The Spearman’s correlation analysis between the HAS and RGB scores.

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Fig 11 Expand

Table 5.

Number of patients in the five HAS score categories before treatment and at each time point after treatment.

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Table 5 Expand

Fig 12.

Angiotensin II at each treatment time.

** p<0.01.

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Fig 12 Expand

Fig 13.

The Pearson’s correlation analysis between Ang II and the RGB score.

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