Fig 1.
Flow diagram showing study selection process.
Table 1.
Characteristics of included studies.
Table 2.
Critical appraisal of included studies.
Fig 2.
Forest plot of comparison of the risks of POCD or POD in patients with or without ApoE4.
Abbreviations: POCD, postoperative cognitive dysfunction; POD, postoperative delirium.
Fig 3.
Small-study effect test for POCD or POD.
(a) Small-study effect test of POCD at 1 week. (b) Small-study effect test of POCD at 1–3 months. (c) Small-study effect test of POCD after 1 year. (d) Small-study effect test of POD. Abbreviations: POCD, postoperative cognitive dysfunction; POD, postoperative delirium.
Table 3.
Sensitivity analyses: Effect of different research characteristics on POCD or POD with ApoE4 carriers.
Table 4.
Trial sequential analysis of the incidence of POCD or PODa.