Fig 1.
Study flow.
Table 1.
Demographic and disease characteristics of NSCLC sample (N = 186).
Table 2.
Associations between systemic inflammation ratios (SIRs) and overall survival.
Fig 2.
Kaplan Meier survival curve for NSCLC patients stratified by NLR systemic inflammation, NLR < 5 and NLR ≥ 5 (n = 184), showing worse survival probability (p = 0.001) for patients having greater inflammation (i.e., above NLR cutoff).
Fig 3.
Kaplan Meier survival curve for NSCLC patients stratified by PLR systemic inflammation, PLR < 185 and PLR ≥ 185 (n = 184), showing worse survival probability (p = 0.005) for patients having greater inflammation (i.e., above PLR cutoff).
Fig 4.
Kaplan Meier survival curve for NSCLC patients stratified by ALI systemic inflammation, ALI < 24 and ALI ≥ 24 (n = 182), showing worse survival probability (p<0.005) for patients having greater inflammation (i.e., below ALI cutoff).
Table 3.
Associations between depression symptoms (PHQ-9) and systemic inflammation ratios at baseline.
Fig 5.
NSCLC patients classified into PHQ/NLR subgroups.
Patients with no/low depressive symptoms were as likely to have low NLRs (<5; 50%) as have high NLRs (≥5; 50%). In contrast, for patients with moderate/severe depressive symptoms, significantly more patients had prognostically worse, high NLRs (≥5; 58%) rather than low NLRs (<5; 42%). Percentage data are provided with error bars.
Fig 6.
NSCLC patients classified into PHQ/PLR subgroups.
Patients with no/low depressive symptoms were as likely to have low PLRs as to have high PLRs (left side). In contrast, for patients with moderate/severe depressive symptoms, significantly more patients had prognostically worse, high PLRs rather than low PLRs (right side). Percentage data are provided with error bars.
Fig 7.
NSCLC patients classified into PHQ/ALI subgroups.
Patients with no/low depressive symptoms were as likely to have low ALIs as to have high ALIs (left side). In contrast, for patients with moderate/severe depressive symptoms, significantly more patients had prognostically worse, low ALIs rather than high ALIs (right side). Percentage data are provided with error bars.