Fig 1.
Abbreviations: HCV, hepatitis C virus; RNA, ribonucleic acid; n, number; HCVcAg, hepatitis C virus core antigen; DAA, direct acting antiviral; RVR, rapid virological response; ETR, end of treatment response; SVR, sustained virological response; SOF, sofosbuvir; LDV, ledipasvir; DCV, daclatasvir; VEL, velpatasvir; RBV, ribavirin; GT, genotype.
Table 1.
Baseline demographic, clinical and virological characteristics of 423 study patients.
Fig 2.
Treatment response rate assessed by HCV RNA & HCVcAg at various time points.
(A)Treatment-naïve (n = 383). Mean HCVcAg levels (log IU/mL) in HCV RNA negative individuals at ETR (n = 6), SVR12 (n = 5), SVR24 (n = 2) & SVR74 (n = 1) are 3.8, 3.7, 3.5 & 3.39 respectively. (B) Previously treated (n = 40). HCVcAg levels (log IU/mL) in HCV RNA negative individuals at SVR24 (n = 1) & SVR50 (n = 1) are 4.1 & 3.46 respectively. Abbreviations: HCV, hepatitis C virus; HCVcAg, hepatitis C virus core antigen; RVR, rapid virological response; ETR, end of treatment response; SVR, sustained virological response.
Fig 3.
Kinetics of HCV RNA & HCVcAg at various time points.
(A) Treatment-naïve (n = 383). (B) Previously treated (n = 40). Abbreviations: HCV, hepatitis C virus; HCVcAg, hepatitis C virus core antigen; LLOQ, lower limit of quantification RVR, rapid virological response; ETR, end of treatment response; SVR, sustained virological response; *NA: not applicable.
Fig 4.
Baseline correlation between HCV RNA and HCVcAg.
(A) Treatment-naïve. (B) Previously treated. Abbreviations: HCV, hepatitis C virus; RNA, ribonucleic acid; HCVcAg, hepatitis C virus core antigen; LLOQ, lower limit of quantification.
Fig 5.
RVR rate in various DAA regimens (A) Treatment-naïve. (B) Previously treated.
Abbreviations: HCV, hepatitis C virus; RNA, ribonucleic acid; HCVcAg, hepatitis C virus core antigen; RVR, rapid virological response; SOF, sofosbuvir; LDV, ledipasvir; DCV, daclatasvir; VEL, velpatasvir; RBV, ribavirin; *NA: not applicable.
Fig 6.
RVR rate in various genotypes (A) Treatment-naïve. (B) Previously treated.
Abbreviations: HCV, hepatitis C virus; RNA, ribonucleic acid; HCVcAg, RVR, ribonucleic acid; hepatitis C virus core antigen; RVR, rapid virological response; GT, genotype; *NA: not applicable.
Fig 7.
Baseline HCV RNA and HCVcAg levels in various genotypes (A) Treatment-naïve (B) Previously treated.
Abbreviations: HCV, hepatitis C virus; RNA, ribonucleic acid; HCVcAg, hepatitis C virus core antigen.
Fig 8.
RVR rate based on CTP & MELD scores.
(A) Treatment-naïve. (B) Previously treated. Abbreviations: HCV, hepatitis C virus; RNA, ribonucleic acid; HCVcAg, RVR, rapid virological response; hepatitis C virus core antigen; CTP, child-turcotte-pugh; MELD, model for end stage liver disease; *NA: not applicable.