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Fig 1.

Flowchart of the method for the development of the classification models.

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Table 1.

Demographic and clinical characteristics in participants with and without coronary atherosclerosis1.

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Table 2.

Demographic and clinical characteristics in participants with and without obstructive coronary artery disease (CAD)#.

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Fig 2.

a. AUC comparison between different models for the prediction of coronary atherosclerosis. (Model 1: Inclusion of traditional cardiovascular risk factors only; Model 2: Inclusion of retinal information only; Model 3: Inclusion of traditional cardiovascular risk factors and retinal information). b. AUC comparison between different models for the prediction of obstructive coronary artery disease. (Model 1: Inclusion of traditional cardiovascular risk factors only; Model 2: Inclusion of retinal information only; Model 3: Inclusion of traditional cardiovascular risk factors and retinal information).

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Table 3.

Stepwise logistic regression analysis showing factors associated with coronary atherosclerosis in different models.

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Table 3 Expand

Table 4.

Stepwise logistic regression analysis showing factors associated with obstructive coronary artery disease in different models.

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Fig 3.

a & b show the retinal images of two participants with coronary artery disease. White arrow indicates arteriole occlusion. Black arrow indicates a venous vessel with significant vascular tortuosity. The dashed white arrow indicates a venous bifurcation; θ1 and θ2 specify the bifurcation coefficients of the two branching venules (MBCV).

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Fig 3 Expand