Table 1.
Sequences of primers used for qPCR.
Fig 1.
Reduced numbers of newly formed oligodendrocytes and Dusp15 expression in MyRF(-/-) mice.
A) Representative histology images from MyRF(-/-) and MyRF(+/-) mice. B) Diagram showing representative region of the corpus callosum stained (bregma 0.86mm; interaural 4.66 according to the Paxinos and Franklin mouse brain atlas). For each animal three coronal sections were imaged with two images counted per section C) The number of YFP+/CC1+ cells was reduced in the corpus callosum of MyRF(-/-) mice. D) Dusp15 expression was found to be lower in the hippocampus of MyRF(-/-) mice. Data presented mean ± SEM **p = 0.004, *p = 0.029.
Fig 2.
Object recognition memory in MyRF(-/-) and MyRF(+/-) mice.
A) Objects used for object recognition testing. B) No difference seen in exploration time during the training session or C) object discrimination index during testing. Data presented mean ± SEM.
Fig 3.
MyRF(-/-) and MyRF(+/-) have equivalent behaviour in the 5-choice serial reaction time task.
No differences were seen in A) accuracy B) correct choices C) premature responses D) omissions, E) response latency F) or reward latency during test A-C. Data presented mean ± SEM. Abbreviations: day before testing started (Pre), post-test A (PTA), post-test B (PTB), post-test C (PTC).
Fig 4.
White noise bursts did not impact 5CSRTT performance in the MyRF(-/-) mice compared with MyRF(+/-) controls.
No differences were seen in A) omissions B) premature responses C) accuracy or D) correct responses. A white noise burst was presented at one of four time points, 0.5, 2.5, 4.5 or 5 seconds prior to stimulus onset. In one in every five trials, no white noise distractor was presented. Data presented mean ± SEM.