Table 1.
Genotype distribution at a diallelic marker in a case-control study.
Fig 1.
Power comparison between the Jonckheere-Terpstra trend test (TJT) and the Cochran−Armitage trend test .
The black solid line denotes TJT and the red dashed line denotes . Along the x-axis, θ = π/4, arctan 2, and π/2 correspond to dominant (D), additive (A), and recessive (R) genetic models, respectively. The y-axis is the average empirical power at the 0.05 level based on 10,000 replicates each. The disease prevalence equals 0.1. MAF: minor allele frequency.
Table 2.
Percent difference between the Jonckheere-Terpstra trend test statistic (TJT) and the Cochran-Armitage trend test statistic () based on the expectation of genotype distributions under dominant, additive, and recessive genetic models.
Fig 2.
Comparison between the Jonckheere-Terpstra trend test (TJT) and the Cochran−Armitage trend test in four real datasets.
A denotes the minor allele; ri′s and si′s are as defined in Table 1.