Table 1.
Pharmacokinetic parameters.
Fig 1.
Extended regimen mean simulated concentration-time profiles for EE and LNG at 1, 3 and 12 weeks.
Mean concentration–time profile of (A) EE and (B) LNG for extended regimen for weeks 1, 3, and 12, overlaid for the elapsed simulated time interval. EE, ethinyl estradiol; LNG, levonorgestrel.
Fig 2.
Extended regimen plasma concentration-time curves for EE and LNG from 0 to 168 hours.
Box plots of (A) EE AUC(0–168) and (B) LNG AUC(0–168) for extended regimen at weeks 1, 3, and 12. Solid line = median; box edges = 25% and 75% quartiles (IQR); whiskers = lowest/highest values within 1.5× IQR of the lower/upper quartiles; circles = observations beyond whiskers; * = mean. AUC(0–168), area under the concentration curve from 0 to 168 hours; EE, ethinyl estradiol; LNG, levonorgestrel.
Table 2.
Summary of EE pharmacokinetic parameters for extended-cycle regimen by week.
Table 3.
Summary of LNG pharmacokinetic parameters for extended-cycle regimen by week.