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Fig 1.

Epidemiological model and economic model.

Graphical representation of the model.

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Table 1.

Clinical and epidemiological data.

Data used to populate the first part of the model.

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Table 1 Expand

Table 2.

Transition probabilities.

Probabilities of transitioning among patients’ states.

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Table 2 Expand

Table 3.

Economic data.

Economic data used to populate the model.

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Table 3 Expand

Table 4.

Epidemiology.

Results of the first simulation phase.

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Table 4 Expand

Fig 2.

Transfers to ICU– 20 weeks.

Yellow bars: standard of care. Orange bars: cas&im treatment.

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Fig 2 Expand

Table 5.

Costs.

Results of the second simulation phase.

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Table 5 Expand

Fig 3.

CE plane.

Relationship between incremental costs and incremental ICUs.

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Fig 3 Expand

Fig 4.

CE plane.

Relationship between incremental costs and incremental deaths.

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Fig 5.

Avoided ICUs.

Results of the univariate sensitivity analysis focused on ICUs.

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Fig 6.

Avoided deaths.

Results of the univariate sensitivity analysis on avoided deaths.

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Fig 7.

Savings.

Results of the univariate sensitivity analysis on savings.

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