Fig 1.
Summary of parameters extracted from macular OCT images.
(A) Retinal layers: retinal nerve fiber layer (RNFL), ganglion cell–inner plexiform layer (GCIPL), inner nuclear layer (INL), outer nuclear and plexiform layer (ONPL), and external limiting membrane–Bruch’s membrane complex (ELM-BM). (B) ETDRS sectorization. (C) 20 x 20 square grid sectorization. (D) Segmentation of top and bottom boundaries. (E) Studied foveal pit geometrical descriptors. (F) Foveal pit radial analysis.
Table 1.
Subject demographic data.
Fig 2.
Percentual change in retinal thicknesses as a function of age for the 3 mm radius circular macular region.
Individual absolute thickness values were transformed into percentages as the relative difference with respect to the average thickness in the youngest group (age < 40). Layers under study: total retinal thickness (TRT), retinal nerve fiber layer (RNFL), ganglion cell–inner plexiform layer (GCIPL), inner nuclear layer (INL), outer nuclear and plexiform layer (ONPL), and external limiting membrane–Bruch’s membrane complex (ELM-BM).
Table 2.
Regression results of mean macular layer thickness.
Fig 3.
Thickness analysis results for the 20 x 20 regular grid sectorization.
(A) Population mean thicknesses. (B) Age-related changes of retinal layer thicknesses measured as % of change per 10 years (top) and corresponding p-values (bottom). (C) Sex differences in percentual units for males (top) and associated p-values (bottom). Percentual values were calculated after transforming absolute thickness values into the relative difference with respect to the average thickness of participants younger than 40 years old. P-values are reported in logarithmic scale after false discovery rate correction. Layers under study: total retinal thickness (TRT), retinal nerve fiber layer (RNFL), ganglion cell–inner plexiform layer (GCIPL), inner nuclear layer (INL), outer nuclear and plexiform (ONPL), and external limiting membrane–Bruch’s membrane complex (ELM-BM).
Table 3.
Regression results for foveal pit morphology.
Fig 4.
Radial analysis of rim height, rim radius and mean slope.
(A) Population mean (central colored line indicates the mean, shaded region depicts the 2.5 and 97.5 percentiles). Percentual effect of age (B) and sex (C) are shown as the normalized regression coefficients (βage and βsex) for each of the 24 angular directions. The shaded region illustrates the 95% confidence interval while the dashed black circle locates the origin (coefficients equal to zero).
Table 4.
Sensitivity analysis results for average macular and foveal parameters.