Fig 1.
Schematic diagram for synthesis of ester derivatives of 3-((5-(dimethylcarbamoyl) pyrrolidin-3-yl) thio)-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0] heptane-2-carboxylic acid.
Fig 2.
Chemical structures of Meropenem and its synthesized derivatives M1-M8.
Table 1.
The results of antibacterial studies were determined and tabulated against gram-positive and gram-negative bacterial strains.
Table 2.
The results of urease inhibition assay of meropenem and its derivatives.
Table 3.
DPPH radical scavenging activity of meropenem, its derivatives (M1-M8) and ascorbic acid.
Table 4.
The results of In-silico molecular docking of the parent molecule and its structural analogues.
Table 5.
Predicted ADME properties of derivatives of 3-((5-(dimethylcarbamoyl)pyrrolidin-3-yl)thio)-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid.
Fig 3.
In-silico molecular docking of ligands with urease (4H9M).
Fig 4.
In-silico molecular docking of ligand with alpha amylase (5E0F).
Fig 5.
Egg plot "a correlation between antibacterial activity and ADME parameter.