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Fig 1.

Study design flowchart and data screening flowchart.

(A) Study design flowchart; (B) Data screening flowchart. Abbreviations: DFU, diabetic foot ulcer; DT, decision tree; LR, logistic regression; RF, random forest; SMOTE, synthetic minority oversampling technique; SVM, support vector machine; XGBoost, extreme gradient boosting.

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Table 1.

Calculation formulae for the evaluation indicators of the model.

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Table 2.

Results of univariate analysis of minor amputation for diabetic foot ulcer patients.

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Table 3.

Data distribution of both the training set and validation set before and after SMOTE.

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Fig 2.

Confusion matrix of the risk prediction models with machine learning algorithms.

(A) DT: decision tree. (B) RF: random forest. (C) LR: logistic regression. (D) SVM: support vector machine. (E) XGBoost: extreme gradient boosting.

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Fig 3.

Performance comparisons of machine learning algorithms after over-sampling.

Abbreviations: DT, Decision Tree; RF, Random Forest; LR, Logistic Regression; SVM, Support Vector Machine; XGBoost, extreme gradient boosting; AUC, area under the curve.

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Fig 4.

ROC curves for predicting minor amputation in DFU patients with machine learning algorithms after over-sampling.

Abbreviations: ROC, receiver operating characteristic curve; DFU, diabetic foot ulcers; DT, decision tree; RF, random forest; LR, logistic regression; SVM, support vector machine; XGBoost, extreme gradient boosting; FPR, false positive rate; TPR, true positive rate.

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Table 4.

Performance parameter values for five machine learning algorithms before and after over-sampling.

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Fig 5.

Feature importance ranking of the included feature of the XGBoost model.

Abbreviations: XGBoost, extreme gradient boosting.

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