Fig 1.
The flowchart of the study recruiting.
Fig 2.
The workflow of the predictive model building in the study.
Table 1.
Demographics and clinical measurements (mean ± SD).
Table 2.
Repeated measures analysis of variance in clinical measurements.
Fig 3.
Model performance and feature selection.
(A) Flow diagram of 60 features filtered by the linear support vector classification. The different colors represent different networks. (B) The result of 5,000 times permutation test in model performance evaluation. The red line is the result of the random forest model, and the blue line is the dummy classification. (C) The result of 5,000 times permutation test, which was repeated 10 times, in feature importance ranking. The size of the circle represents the standard deviation score, and the red line is the importance coefficient = 0.15. (D) The correlation diagram of 60 features filtered by the linear support vector classification. The different colors in ROI represent different networks.
Table 3.
Network comparison of features (mean ± SD).
Fig 4.
The changed functional connections of brain nodes in the CFS group with P < 0.05 between interventions.
The different colors of brain nodes represent different brain networks. The thickness of nodes’ connections represents the statistical value between interventions; the statistical value that was decreased after the intervention is displayed with blue color and that which was increased with pink color.
Fig 5.
The changed functional connections of brain nodes in the HC group with P < 0.05 between interventions.
The different colors of brain nodes represent different brain networks. The thickness of nodes’ connections represents the statistical value between interventions. The statistical value that was decreased after the intervention is displayed with blue color and that which was increased with pink color.
Table 4.
Bilateral network comparison of features (mean ± SD).
Fig 6.
The result of the partial correlation test in the CFS patient group.
The result of the partial correlation test between changes of the left frontoparietal network and the default mode network in the CFS group. All the changes and differences were calculated by post- minus pre-.