Fig 1.
Flow chart of patient selection.
Fig 2.
Treatment algorithm applied in the simulation study.
Scenario (1) is shown in green, scenario (2) in orange. Percentages refer to the prior step of the algorithm. Slightly different patient numbers between consecutive steps of the simulation algorithm are the result of summarizing the counts of respective patients across the 10,000 simulations by the median. Notes: * Numbers of patients achieving the LDL-C goal are provided for scenario (2). The numbers slightly differed for scenario (1) with n = 67,853 (96.5%) of patients achieving the LDL-C target and n = 2,428 (3.5%) not. BA: Bempedoic acid, PCSK9i: PCSK9 inhibitor, LDL-C: Low-density lipoprotein cholesterol.
Table 1.
Baseline characteristics.
Fig 3.
LDL-C target attainment in the total cohort and stratified by risk as observed and simulated.
LDL-C concentrations are given as median (interquartile range). LDL-C: Low-density lipoprotein cholesterol. LLT: Lipid-lowering therapy.
Table 2.
Drug costs, prevented atherosclerotic cardiovascular disease events, and cost per prevented event.