Table 1.
Demographic and clinical characteristics of the studied population with their relative percentages.
Fig 1.
Resulting networks at the onset of the study (T0).
Part A represents the network of patients with MDD. Part B represents the network of Type I BD patients. Pink color groups the neurocognitive domain, green color the psychosocial domain and blue color the depression-related nodes. Black edges represent positive Spearman correlations, red edges negative Spearman correlations. The blue ring around each node represents its predictability and the fuller the bar is, the higher the RMSE value is. Cognitive domain: MoCA = Montreal Cognitive Assessment, MMS = Mini Mental State Examination, FAB = Frontal Assessment Battery, FAS = Phonetic verbal Fluency, Vcb = Vocabulary, REY = Rey 15 Words immediate recall, RDC = Rey 15 Words deferred recall, SPAN_A = digit span forward, SPAN_I = digit span backward. Depression related domain (blue color in the images): BDI = Beck depression inventory II, HDR = Hamilton depression rating scale. Psychosocial domain (green color in the images): Cgn = Cognitive functioning, Occ = occupational functioning, Atn = Autonomy, Lsr = Leisure time, Int = interpersonal relationships, Fnn = financial issues.
Fig 2.
Centrality measures (strength, betweenness, closeness) of MDD and BD patients at baseline (T0).
Red color represents Bipolar Patients and Blue Color MDD patients. MoCA = Montreal Cognitive Assessment, MMS = Mini Mental State Examination, FAB = Frontal Assessment Battery, FAS = Phonetic verbal Fluency, Vcb = Vocabulary, REY = Rey 15 Words immediate recall, RDC = Rey 15 Words deferred recall, SPAN_A = digit span forward, SPAN_I = digit span backward, BDI = Beck depression inventory II, HDR = Hamilton depression rating scale, Cgn = Cognitive functioning, Occ = occupational functioning, Atn = Autonomy, Lsr = Leisure time, Int = interpersonal relationships, Fnn = financial issues.
Fig 3.
Resulting networks at first endpoint (T1).
Time 1 of the study (T1). Part A represents the cluster of MDD. Part B represents the network of type I BDs. Pink color groups the neurocognitive domain, green color the psychosocial domain and blue the depression-related nodes. Black edges represent positive Spearman correlations, red edges negative Spearman correlations. The blue ring around each node represents its predictability and the fuller the bar is, the higher the RMSE value is. Cognitive domain: MCA = Montreal Cognitive Assessment, MMS = Mini Mental State Examination, FAB = Frontal Assessment Battery, FAS = Phonetic verbal Fluency, Vcb = Vocabulary, REY = Rey 15 Words immediate recall, RDC = Rey 15 Words deferred recall, SPAN_A = digit span forward, SPAN_I = digit span backward. Depression related domain (blue color in the images): BDI = Beck depression inventory II, HDR = Hamilton depression rating scale. Psychosocial domain (green color in the images): Cgn = Cognitive functioning, Occ = occupational functioning, Atn = Autonomy, Lsr = Leisure time, Int = interpersonal relationships, Fnn = financial issues.
Fig 4.
Centrality measures (strength, betweenness, closeness) of MDD and BD patients at first endpoint (T1).
Red color represents BD and Blue Color MDD. MCA = Montreal Cognitive Assessment, MMS = Mini Mental State Examination, FAB = Frontal Assessment Battery, FAS = Phonetic verbal Fluency, Vcb = Vocabulary, REY = Rey 15 Words immediate recall, RDC = Rey 15 Words deferred recall, SPAN_A = digit span forward, SPAN_I = digit span backward, BDI = Beck depression inventory II, HDR = Hamilton depression rating scale, Cgn = Cognitive functioning, Occ = occupational functioning, Atn = Autonomy, Lsr = Leisure time, Int = interpersonal relationships, Fnn = financial issues.
Fig 5.
Domains and their possible interaction in MDD and BD.
Part A: Possible interactions among domains for MDD by analyzing patients’ test performance and resulting networks. Part B: Possible interactions among domains for BD by analyzing patients’ test performance and resulting networks. Color coding is consistent with network images. Black arrows represent the main path of interactions between studied functions. Red arrows should be interpreted as a secondary effect due to black arrows.