Fig 1.
Flow chart of patient classification during study.
BOS: Bronchiolitis obliterans syndrome; CLAD: Chronic lung allograft dysfunction; FEV1: Forced expiratory volume in one second; FVC: Forced vital capacity; RAS: Restrictive allograft syndrome.
Fig 2.
Lung volume progression during follow-up.
A) Lung volume during follow-up for persistent BOS, B) lung volume during follow-up for BOS-to-RAS transition. Data presented as median with interquartile range. BOS: Bronchiolitis obliterans syndrome; CLAD: Chronic lung allograft dysfunction; RAS: Restrictive allograft syndrome.
Table 1.
Recipient and donor characteristics, time to CLAD onset and BOS to RAS transition.
Table 2.
Pulmonary function tests at CLAD onset.
Table 3.
Radiological analysis.
Fig 3.
Impact of class change on survival.
A) Recipient survival after lung transplantation, B) graft survival after lung transplantation, C) recipient survival after CLAD onset and D) graft survival after CLAD onset. Impact analyzed with Kaplan-Meier survival curves using the log rank -test. BOS: Bronchiolitis obliterans syndrome; CLAD: Chronic lung allograft dysfunction; RAS: Restrictive allograft syndrome.
Table 4.
a. Cox regression analysis on risk factors for BOS to RAS transition.
b. Multivariate Cox regression analysis on risk factors for BOS to RAS transition.