Fig 1.
CONSORT participant flow diagram.
Table 1.
Study participant demographic and smoking characteristics pre-randomization.
Table 2.
Means at baseline (visit 4)* and end of randomized phase (visit 10) for each group and results of statistical comparisons based on linear regression models.
Fig 2.
2A-2D. Changes in plasma cotinine, exhaled CO, daily cigarette consumption, and FTND nicotine dependence score among completers (n = 143) smoking either Usual Nicotine Content (n = 74) cigarettes or Reduced Nicotine Content (n = 69) cigarettes. * indicates statistically significant between group difference at Visit 10, controlling for Visit 4 baseline.
Fig 3.
3A-3D. Changes in OASIS, QIDS, PSS, and NNAL# among completers (n = 143) smoking either Usual Nicotine Content (n = 74) cigarettes or Reduced Nicotine Content (n = 69) cigarettes. * indicates statistically significant between group difference at Visit 10, controlling for Visit 4 baseline. # urine NNAL measured in randomly selected subgroup (n = 26 on RNCs and n = 25 on UNCs, evenly stratified by site and by study group), who provided urine samples at randomization (v4) and at the end of the randomized phase of the trial (v10).
Fig 4.
The proportion of participants initially randomized to reduced nicotine content or usual nicotine content cigarettes who had quit smoking cigarettes at visit 11, and at visit 12.
*p<0.01 for comparison between proportion randomized to RNC and UNC group who reported no cigarettes smoked in the previous week with exhaled CO<10ppm.