Table 1.
Descriptive statistics of study population.
Table 2.
Details of genetic variants and MAFs in global, SAS and studied population.
Fig 1.
Comparison of minor allele frequencies (MAFs) based on BMI categories.
The BMI categories-based distribution of the MAFs of all genetic variants is presented as bar graph. The y-axis represents frequencies of the minor alleles per BMI categories (Normal, Lean, Over-weight, Obese, and Over-weight + Obese) while genetic variants with corresponding minor alleles are shown in the x-axis. MAFs were calculated using online software SNPStats.
Fig 2.
Association analysis of minor alleles with BMI stratified categories.
Associations of genetic variants with BMI based categories (Lean and Over-weight + Obese) were obtained by Odds ratios (ORs) with 95% confidence intervals (95% CI). ORs (95% CI) were calculated using age and gender adjusted logistic regression models and normal BMI category considered as reference group with an OR = 1.0.
Fig 3.
BMI raising risk effect size estimation of minor alleles.
The BMI raising risk effect size of all genetic variants are presented as β-coefficients (SE) in total and gender based (Male vs female) population cohort obtained by linear regression analysis. The positive β-coefficient values represent an increase in BMI (Kg/m2) while a negative value showed a decrease in BMI (Kg/m2) for each copy of the minor allele of a variant.