Table 1.
Baseline demographic, clinical, and MRI characteristics of subjects.
Fig 1.
Comparison of limbic region volume between MS and control patients.
The mean (95% CI) percentage of total intracranial volume occupied by limbic nuclei that were significantly different between the groups. ANCOVA analyses adjusted for patient race, age, sex, and BMI. The p-value for each comparison are presented and an asterisk (*) indicates the comparison remained statistically significant following application of the Bonferroni correction.
Table 2.
Spearman correlation coefficients between T2 Lesion volume or BPF and individual limbic regions or the total area.
Table 3.
Unadjusted and adjusted regression analysis in MS patients.
Fig 2.
VBM analysis of limbic regions in MS.
Fornix and anterior nuclei group are atrophied compared to controls, voxel-wise threshold p < 0.05 (uncorrected) and extent threshold K >0, adjusted for covariates TIV, age, sex, race, and BPF.