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Fig 1.

The four stages of lung cancer development.

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Fig 2.

The constituent steps of the proposed method.

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Fig 3.

The 3D-GLCMs are computed from VSs of nodule volume and fed to a recurrent neural network.

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Fig 4.

In 2.5D-GLCM mode the GLCMs computed for each slice are fed to the recurrent neural network.

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Table 1.

The structure of the proposed LSTM-based fusion method.

f refers to the number of elements in the extracted features.

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Table 2.

The comparison of WSA-Otsu with counterpart methods.

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Fig 5.

The convergence curves of Otsu method in terms of fitness values at five different levels.

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Fig 6.

The thresholding time of the proposed method vs. other counterparts.

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Fig 7.

ROC curves for three fusion models and their corresponding macro-averaged AUC values.

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Fig 8.

ROC curves for three fusion models and their corresponding micro-averaged AUC values.

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Table 3.

A comparison between the proposed 2D and 2.5D GLCM fusion methods and other deep CNN-based methods regarding the accuracy, sensitivity, and specificity metrics.

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Table 4.

A comparison between the proposed fusion methods for different modes of GLCM computation and the recently proposed classification methods regarding the accuracy, sensitivity, and specificity metrics.

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Fig 9.

ROC curves for baseline and proposed models, and their corresponding micro-averaged AUC values.

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Fig 10.

ROC curves for baseline and proposed models, and their corresponding macro-averaged AUC values.

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Table 5.

The classification results in terms of micro-averaged AUCs trained on the LIDC-IDRI dataset and tested on LIDC-IDRI and LUNGx datasets for the proposed and baseline models.

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Table 6.

The T-test p-values obtained comparing the average AUC of the LSTM-based deep fusion of 3D-GLCMs with other baseline models.

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Table 7.

Results of the ablation study for the type of features presented to the LSTM-based deep fusion model.

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Fig 11.

The training time of different models for five epochs.

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Fig 12.

The test time of different models.

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