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Table 1.

Comparison of agent-based models for HIV transmission.

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Fig 1.

The care and treatment system.

A flowchart of the stages of the HIV treatment cascade that agents in the LHM can go through.

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Table 2.

Levels of prevention and care levers used in the simulations.

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Table 2 Expand

Fig 2.

Incidence by age: Observed and predicted annual incidence cases by age, the modeled 80% prediction range (grey), the modeled mean value (red), and the count observed in 2016 field data from the Chicago Department of Public Health.

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Table 3.

Observed and predicted annual incidence cases by age.

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Table 3 Expand

Table 4.

Observed and predicted rates of HIV incidence for MSM by Race/Ethnicity.

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Fig 3.

Pathways toward interim EHE goal, 75% reduction of incidence by 2025.

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Fig 4.

Pathways toward final EHE goal, 90% reduction of incidence by 2030.

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Fig 5.

A comparison of care cascades between continuation of 2015 baseline levels vs. optimal path toward the 2030 goal of 90% reduction, for both prevention (left) and treatment (right).

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Fig 6.

Projected incidence over time: Projected number of incidence cases over time for the baseline model (blue) and the optimal 90% reduction scenario (green).

Solid line shows the mean projection; colored surface, the 80% Prediction Interval. The black line shows observed levels based on the most recent CDPH surveillance data.

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Fig 7.

Projected number of incidence cases over time based on Bayesian posterior predictive distribution: Solid line shows the mean projection; colored surface, the 80% Prediction Interval.

The black line shows observed levels based on the most recent CDPH surveillance data.

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Fig 8.

Projected number of incidence cases over time for extreme scenarios: Projected incidence over time for 90% reduction (green); the ART-only scenario that maximizes only ART related levers (yellow); and the PrEP-only scenario that maximizes only PrEP related levers (purple).

The solid line represents the mean of each projection; colored surface, the 80% Prediction Interval.

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