Fig 1.
Flow chart of the epidemiological sturdy 2018.
The study comprises the first survey and the second survey.
Table 1.
Diagnostic criteria for MG.
Fig 2.
Distribution of onset age of total MG patients.
(A) Histogram of onset age of total patients. Median (IQR) = 59 (43–70) years old. (B) Histogram of onset age by sex. Median (IQR): male; 60 (49–69) years old, female; 58 (40–72) years old. The male was significantly older than the female [Wilcoxon-Mann-Whitney test (WMW), p = 0.0299].
Table 2.
Comparison of demographic features among nationwide surveys in Japan.
Fig 3.
Box plot and violin plot of onset age by categories. The horizontal line within the box represents the median value. The box ends to define the 25th and 75th quantiles, expressed as the first and third quartiles. The lines that extend from the box end are whiskers. The whiskers extend from the ends of the box to the outermost data point that falls within these distances. 1st quartile–1.5 x (interquartile range), 3rd quartile+1.5 x (interquartile range). For statistical analysis, Steel-Dwass All Pairwise Comparison was performed.
Table 3.
Male to female ratio by categories.
Table 4.
Initial symptoms of patients.
Fig 4.
Maximum AChRAb titer of AChRb(+)Tm(-) and AChRAb(+)Tm(+).
Box and violin plots of maximum titer of AChRAb of anti-acetylcholine receptor antibody (AChRb) (+) thymoma (Tm) (-) and AChRAb(+)Tm(+). The horizontal line within the box represents the median value. The box ends to define the 25th and 75th quantiles, also expressed as the first and third quartiles, respectively. The lines that extend from the box end are whiskers. The whiskers extend from the ends of the box to the outermost data point that falls within these distances. 1st quartile–1.5 x (interquartile range), 3rd quartile+1.5 x (interquartile range). For statistical analysis, we used Wilcoxon-Mann-Whitney test (WMW).
Table 5.
Examination to evaluate NMJ function.
Table 6.
Comorbidities and family history of MG.
Fig 5.
Myasthenia gravis activities of daily living profile by categories.
(A) Box and violin plots of myasthenia gravis activities of daily living profile (MG-ADL) at the severest state. (B) Box and violin plots of MG-ADL at the current state. The horizontal line within the box represents the median value. The box ends represent the 25th and 75th quantiles, expressed as the first and third quartiles. The lines that extend from the box end are whiskers. The whiskers extend from the ends of the box to the outermost data point that falls within these distances. 1st quartile–1.5 x (interquartile range), 3rd quartile+1.5 x (interquartile range). For statistical analysis, Steel-Dwass All Pairwise Comparison was performed.
Fig 6.
Myasthenia Gravis Foundation of America (MGFA) clinical classification by myasthenia gravis categories.
Bar graph plot of Myasthenia Gravis Foundation of America (MGFA) clinical classification of myasthenia gravis (MG) categories. The clinical classification was done according to maximum disease severity. The X-axis indicates categories of MG. Y-axis indicates the patients’ number.
Table 7.
Therapies and outcome by categories.
Fig 7.
Prednisolone (PSL) dose at the maximum and the current states.
(A) Box and violin plot plots of prednisolone (PSL) at maximum dose. (B) Box and violin plot of PSL at the current dose. The horizontal line within the box represents the median value. The box ends represent the 25th and 75th quantiles, expressed as the first and third quartiles. The lines that extend from the box end are whiskers. The whiskers extend from the ends of the box to the outermost data point that falls within these distances. 1st quartile–1.5 x (interquartile range), 3rd quartile+1.5 x (interquartile range). For statistical analysis, Steel-Dwass All Pairwise Comparison was performed.