Fig 1.
The constituents of neuroprotective sub-fractions from SCT in previous study.
(tR represents their retention time in UPLC).
Fig 2.
The DPPH clearance percentages of active sub-fractions.
Data were expressed as mean ± S.E.M. from the data obtained from three independent experiments (n = 3). NS represents the mean of group has no significant different with the mean of control group.
Fig 3.
The inhibition percentages of active sub-fractions on AChE.
Data were expressed as mean ± S.E.M. obtained from three independent experiments (n = 3). NS represents the mean of group has no significant difference compared to the mean of control group.
Fig 4.
The inhibition percentages of active sub-fractions on MAOs.
Data were expressed as mean ± S.E.M. obtained from three independent experiments (n = 3). NS represents the mean of group showed no significant difference with the mean of control group.
Fig 5.
The inhibition percentages of active sub-fractions on NMDAR-mediated current.
Data were expressed as mean ± S.E.M. D-AP5 group: n = 4, other groups: n = 3. NS represents the mean of group has no significant different with the mean of control group.
Fig 6.
The intersection of targets from constituents and diseases.
AD: Alzheimer‘s Disease; PD: Parkinson’s Disease; ALS: Amyotrophic Lateral Sclerosis; SCA: Spinocerebellar Ataxia; LBD: Lewy Body Dementia; FTD: Frontotemporal Dementia; HD: Huntington’s Disease.
Table 1.
Overlapping targets of constituents and AD/PD.
Fig 7.
Enrichment analyses for constituents-AD/PD common targets: Biological process.
Fig 8.
Enrichment analyses for constituents-AD/PD common targets: Molecular function and cellular component.
Fig 9.
Enrichment analyses for constituents-AD/PD common targets: KEGG pathway.
Fig 10.
SCT-sub-fraction-constituents-targets-disease network diagram.
Table 2.
The results of topological analysis for the network.
Fig 11.
Surflex-dock results of SCT constituents with key targets in total score.
Fig 12.
Constituents from SCT with their possible targets predicted by total score in surflex-dock.