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Fig 1.

Flow chart showing study enrollment, allocation and number of patients analysed.

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Table 1.

Sociodemographic, medical, psychopathological variables and subjective level of distress of the N = 20 patients with PD with/ without agoraphobia and a sample of healthy controls (N = 20).

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Table 1 Expand

Fig 2.

Heart rate response under Low Intensity Exercise (LIE) in patients with panic disorder and healthy controls.

Abbreviations/ see S3 File: bpm, beats per minute; LIE, low intensity exercise.

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Fig 2 Expand

Fig 3.

Cortisol response under Low Intensity Exercise (LIE) in male patients with panic disorder and healthy controls.

Abbreviations/ see S3 File: LIE, low intensity exercise.

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Fig 3 Expand

Fig 4.

Cortisol response under Low Intensity Exercise (LIE) in female patients with panic disorder and healthy controls.

Abbreviations/ see S3 File: LIE, low intensity exercise.

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Fig 4 Expand

Fig 5.

Correlation between salivary cortisol (AUCg) and the PAS subscale health concerns.

The lower the cortisol response under Low Intensity Exercise (LIE), the lower the improvement (higher percentage of baseline) in PAS health concerns under intensive cognitive-behavioral therapy. Abbreviations/ S3 File: AUCg, Area under the Curve with respect to ground; LIE, low intensity exercise; PAS, Panic and Agoraphobia Scale.

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Fig 5 Expand

Table 2.

Spearman´s correlations between cortisol response under Low Intensity Exercise (LIE) (AUCg/ AUCi) and the PAS score at T1 (n = 20), T2 (n = 13) and percent change in PAS from T1 to T2.

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Table 2 Expand