Table 1.
Patient characteristics, pre- and perioperative parameters.
Fig 1.
Trend in nasopharyngeal temperatures during CPB assisted CABG over time.
Fig 2.
5 year survival per categorized minimal nasopharyngeal temperature per time period, including (a) 1997–2002, (b) 2003–2009 and (c) 2010–2015.
Fig 3.
Survival per minimal nasopharyngeal temperature.
(a) 30-day survival, (b) 5-year survival corrected for 30-day survival (31 days– 5 year), (c) 5-year survival and (d) 5-year survival per degree.
Fig 4.
Survival relative to cooling and rewarming rate.
(a) Density plot of the cooling and rewarming rates. (b) Scatterplot cooling and rewarming rates with plateau temperature (c) Cooling rate– 5-year survival (d) Rewarming rate– 5-year survival.
Table 2.
Multivariate COX regression analysis.
Table 3.
Patient characteristics and preoperative factors based on putative pre-cooling cluster membership for 4351 patients.
Fig 5.
5-year survival per pre-cooling cluster.
(a) 5-year survival is shown and differentiated for all 8 machine learning-based clusters. (b) survival for different nasopharyngeal temperature during CPB within each pre-cooling phenotype. Statistically tested using the long-rank test.