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Fig 1.

Study flow diagram based on PRISMA guidelines.

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Table 1.

Summary of study and patients’ characteristics.

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Table 2.

Risk of bias assessment using Newcastle-Ottawa scale (NOS).

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Table 2 Expand

Fig 2.

Prevalence of bacterial coinfection. (ES (effect size), 95% CI (95% confidence interval)).

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Fig 3.

Antibiotic use.

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Fig 4.

Prevalence of bacterial coinfection by region.

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Fig 5.

Prevalence of bacterial coinfection by study design.

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Fig 6.

Antibiotic use by region.

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Fig 7.

Antibiotic use by study design.

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Fig 8.

Funnel plots illustrating the assessment of publication bias for each primary outcome.

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