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Fig 1.

Patient assessment procedure.

Flowchart of “Patient assessment procedure” depicting a complete set of quadruple measurement-pairs to the same patient within 5 minutes, with every measurement-pair comprising one manual, and one quantitative measurement, to both left and right eye, subsequently, blinded to the other observer.

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Fig 1 Expand

Table 1.

Baseline characteristics.

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Table 1 Expand

Fig 2.

Standard manual versus quantitative pupillometry—Pupil size.

Bland Altman plots depicting intra-, and inter-observer variability of pupil size measured with manual and quantitative pupillometry.

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Fig 2 Expand

Table 2.

Statistical analysis.

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Table 2 Expand

Fig 3.

Additional quantitative pupillary response parameters.

Bland Altman plots depicting intra-, and inter-observer variability of quantitative pupillary response parameter. %CH = percental change, CV = average constriction velocity, MCV = maximum constriction velocity, DV = dilation velocity, LAT = latency of constriction, NPi = Neurological Pupil index, LoA = limit of agreement.

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Fig 4.

Device reproducibility and repeatability.

Bland Altman plots depicting intra-, and inter-device variability of quantitative pupillometry. MAX size = maximum pupillary diameter, MIN size = minimum pupillary diameter, %CH = percental change, CV = average constriction velocity, MCV = maximum constriction velocity, DV = dilation velocity, LAT = latency of constriction, NPi = Neurological Pupil index, LoA = limit of agreement.

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Fig 4 Expand