Fig 1.
The patient selection flow chart.
Abbreviations: OCT, optical coherence tomography.
Table 1.
Characteristics of the study population including mean deviation recorded by Humphrey 24–2 automated perimetry.
For mean deviation PRO n = 22 eyes; Controls n = 51 eyes. Welch’s T-test was used for normally distributed data, Mann-Whitney U test was performed for non-normally distributed data, and Chi-squared was used for nominal data.
Table 2.
RNFL thickness measurements recorded from SD-OCT optic disc and macular cube scan protocols.
One-sided Welch T-test was used to determine significance. The data demonstrate a statistically significant difference in RNFL thickness between PRO and control groups in the temporal quadrant.
Fig 2.
Average RNFL distribution of PRO and controls which were further divided into those with hyperprolactinemia as determined clinically as > 30 ng/ml (NS+) and those with normal prolactin (NS).
For RNFL analysis PRO eyes n = 27, NS+ eyes n = 24, and NS eyes n = 80. RNFL did differ significantly between the groups (p-value 0.0027) using one-way ANOVA. Post Hoc (Tukey) analysis demonstrated significant difference between the NS+ and NS groups (p-value 0.0018). **p-value < 0.01.
Table 3.
Subject characteristics by group including visual ability as mean deviation recorded by Humphrey 24–2 automated perimetry (PRO n eyes = 22, controls NS+ n eyes = 18, controls NS n eyes = 33) and SD-OCT average RNFL thickness (PRO n eyes = 27, controls NS+ n eyes = 24, and NS n eyes = 80).
One way ANOVA was used to determine significance and Chi-squared was used for nominal data.
Fig 3.
Pearson linear regression analysis was performed for all subjects with the controls divided by subgroups (NS+ and NS).
Analysis of PRL as a function of mean deviation in the PRO group revealed little negative association (R = -0.23, p-value = 0.31). When analyzing the controls by subgroups, NS+ demonstrated a significant correlation between mean deviation and serum PRL level (R = 0.51, p-value = 0.035) while the NS group demonstrated an inverse correlation that approached significance (R = -0.47, p-value = 0.0053).