Fig 1.
Venn diagram of the intersections of PCOS and EC.
Intersections represent the differentially expressed genes in PCOS associated data series and EC associated data series.
Fig 2.
The color of the nodes are illustrated from red to yellow in descending order of MCC score. Gray lines highlight the interactions; line thickness refers to the interaction score provided by STRING.
Table 1.
Hub genes identified through PPI analysis.
Fig 3.
Shown are the top 10 most significantly enriched terms of each category based on p-value. The bubbles’ sizes are scaled according to the count of the potential targets enriched in the pathways. The bubbles are colored from red to blue in descending order of p-value. BP, biological process; CC, cell component; MF, molecular function.
Fig 4.
Red nodes represent hub genes of PCOS and EC.
Fig 5.
Genes-TFs interaction network.
Hexagons represent hub genes; circle nodes represent TFs associated with hub genes.
Fig 6.
Genes-miRNAs interaction network.
Hexagons represent hub genes; circle nodes represent miRNAs associated with hub genes.
Table 2.
Candidate drug molecules (top ten) identified from gene-drug interaction enrichment analysis.
Fig 7.
Molecular docking of fenofibrate with proteins of hub genes.
(A). The binding poses of ESR1 complexed with fenofibrate. (B). The binding poses of JUN complexed with fenofibrate. (C). The binding poses of UBE2I complexed with fenofibrate. Hydrogen bonds are indicated as dashed lines.
Table 3.
Docking parameters and results.
Fig 8.
Research flowchart.
Fig 9.
A speculative mechanism diagram of the hub genes in PCOS endometrium carcinogenesis.